Is it possible for me to move from being unemployed, to having a succesfful job before the end of 2006?

I'm sending resume's here and there.. and no one responds. I've already been unemployed since April 2006. I even filled out long applications for office positions at hospitals , i thought them being such institutions would be more helpful, but they too dn't respond. Is my only option to give up trying to get good jobs and pick up babysitting or labor?